Manganelli's goal is improving the capacity of the built environment to enhance human health, well-being and cognition. He is an architect and human factors consultant. His research engages architecture, cognitive science, human factors, systems science, and evolutionary biology. He develops constructs, methods, and tools for placing and analyzing the performance of agents (people, buildings, other organisms, hardware, software) within a shared representational framework. He is the founder of xplr design, a human factors consultancy. He is an architect, human factors consultant, innovation catalyst, and sustainability consultant with Fluor in its Life Sciences and Advanced Manufacturing division. Manganelli teaches information architecture and user experience research and design for Kent State University's School of Information. He is a member of the National Institute of Building Sciences' buildingSMART Alliance Thought Leadership & Information Standards Subcommittees, and a member of the Human Factors and Ergonomics Society's Systems Development, Environmental Design, Macroergonomics, and Cognitive Engineering and Decision Making Technical Groups, serving as Newsletter Editor for the Environmental Design Technical Group. Manganelli is a co-author on the National Institute of Standards and Technology's Internet-of-Things-Enabled Smart-City Framework, is a past volunteer co-chair of the USGBC-SC MLAB, and completed a post-doctoral research fellowship studying distracted driving at CU-ICAR.